Practical Application of Pharmacokinetic-Pharmacodynamic Modeling.
نویسندگان
چکیده
منابع مشابه
Population Pharmacokinetic and Pharmacodynamic Modeling
As we acquire experience with the clinical and pharmacokinetic behavior of a drug, it is very desirable to capture this experience and its related information in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The purpose of population modeling is thus to describe and capture o...
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Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identificat...
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BACKGROUND The aim of this study was to identify the best model to describe pharmacokinetics and pharmacodynamics in prepubertal children and therefore to calculate the corresponding pharmacodynamic parameters. In addition, and to confirm our method, a group of postpubertal subjects was also studied. METHODS Sixteen children (9.5 yr, range 6-12) and 13 adults (22 yr, range 13-35) were include...
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Approved: Thesis Supervisor Title and Department
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 2000
ISSN: 0916-1139
DOI: 10.2133/dmpk.15.452